I spent about an hour and a half setting up the press yesterday once the dies came in. I will say that setting up the dies on the Dillon was MUCH easier than on my Lee Loadmaster. On the Lee, as I set up each die I it would throw off all of the previously set dies, and I ended up constantly having to go back and tweak all of the "set" dies each time I added a new one. It took about 5 hours to set up that press.
I ran 100 rounds through the Dillon as a test. My only complaint is that the plunger on the powder check die occasionally gets hung up on the case mouth and gives me a false warning. Other than that, I found the Dillon to have a smoother stroke and require less effort than any of my Lee presses. It took me 20 minutes to load 100 rounds while carefully watching everything. Compare that to 1-2 hours (depending on the mechanical difficulties encountered) on my Lee progressive presses.