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I've been to SF four times in the last 18 months but it's always about partying with friends. I can say that Don Pistos in North Beach as great Mexican street food. It's a staple for us.
If you really want to take in Napa, you should plan on a hotel for a night or two up there. You'll probably want to spend at least 1.5-2 hrs at each winery.
Enjoy, San Francisco is an incredible city.
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