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Not many plausible explanations, but Occam's Razor typically applies. The problem is figuring out which is the fit.
1. catastrophic decompression at altitude. If this happened, the crew could be out in a matter of seconds with no ability to call things in. Depending on the damage, it might fly for awhile (doubtful) or auger in (more likely). If it did that over sea, you would expect to see some floating debris but it could be a small pattern.
2. other catastrophic failure (airframe, control, comms). One could imagine losing comms combined with some other problem, trying to turn back (or getting lost) and eventually going down.
3. Passenger terrorists - commandeer the cockpit and crash it or plane goes down with a struggle, or blow up a device leading to catastrophic failure.
4. Pilot terrorist act - while others are out of the cockpit, pilot augers in.
I don't see much other explanation.
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