First and foremost, be very alert over there. It is in general a lot more dangerous than most countries.
I would plan and book some overnight travel through the Eastern Cape area. The allure of a secluded, off the beaten path place to stay has some risk to it as they normally are not as secure. There is some good points in this post:
Driving through Transkei with N2 - Eastern Cape Forum - TripAdvisor Personally I would drive to Port Edward and then head to the N2 and use that road until East London.
And be very careful of livestock and pedestrians (who always seem to be wearing darker clothing) if you drive at night.
Again, be careful. And enjoy! This picture was taken from my parents' house this weekend. They live about an hour south of Durban:
