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I literally just went through this. .....
Duane was 15+ years old, wife had him longer than me....
He had an appetite, used the box normally, but was losing weight, took him to the vet. ... everything was pointing at hyperthyroid issues, so we scheduled to bring him back for bloodwork etc..... The night before we were not to feed/water him. .... That morning, I heard his last meow. ... It sounded different. .... Found him laying in his usual spot.... He was gone....
Our home is absolutely different without him.
We had him cremated, it's a service your vet surely provides. .... And something I never even thought about the logistics of until I had to....