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I would build up a larger offset matte border (creating more depth/distance between the artwork and the frame/glass surface). Then, as mentioned, use acrylic plexiglass sheet instead of actual glass. It is lighter, easier to work with (cut), shatter-proof, and is available with MUCH better UV blocking and anti-glare properties than standard glass. No blue/green color-cast either, which you can get with glass. I would probably stick with acrylic (Lucite) over polycarb (Lexan) as well.
If you want to DIY it, any plastics shop should be able to provide the material you need. I've dealt with Laird Plastics and TAP Plastics for poly/acrylic sheets before, and both have several US locations, and can also ship.
If you want someone else to handle it, call a local frame shop. Just be prepared for the jewelry-like mark-up pricing.
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