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On my bathroom half wall about 3' long, I made the bottom frame out of 2"x4"s and then filled in the horizontal space with another 2"x2" so the wall before drywall was 5.5" thick. I then screwed all three 2-bys together and then lag bolted it in 6 places to the two 3/4" thick plywood sub floor.
15 years later, that wall is still holding fast and has seen a lot of slamming doors and leaning people with nary a movement.
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