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I-80 is not the PA Turnpike. I-76 is. Both run east to west, with I-80 being through northern Pennsylvania. 76 runs through southern Pennsylvania and connects Pittsburgh, Harrisburg, and Philadelphia.
I took I-76 from Pittsburgh to Harrisburg yesterday. There was some road construction, but no real delays. Traffic was moving fine. I haven't been on 80 for a long time so I don't know if there is any construction on it now. Both are decent roads. I would think either would be fine.
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