How far away would you be from your vacation rental? Time and distance getting to the vacation home is a huge factor.
My sister has a vacation rental in the Smokies, under 3 hours drive. She only rents to friends and family and families of friends. For family she charges a cleaning fee and $20.00 a day. For friends of family she charges cleaning fee plus $100.00. She has yet to have a bad experience.
The house is designed so that the master bedroom/bath/suite is not rented and remains locked. No one stays in that part of the house. That was key to her...as LKE mentioned
She spends a lot of time there because the drive is under three hours. That seems to be the sweet spot.