If'n you are thinking of spending $1k and physical strength is a concern ...
Just get one of these -
https://www.budsgunshop.com/catalog/product_info.php/cPath/2084_2108/products_id/415001968/Ruger+GP100+327+FED+Blue+5%5C+Half+Lug
Send it some place to have a DAO conversion done (see
Ruger Revolver Gunsmithing - www.GrantCunningham.com www.GrantCunningham.com - not a recommendation, just a google result)
327 is a potent little round, out of a medium size service revolver it will have much less recoil that good 38+p in the same gun. The DAO trigger job should make the trigger a long, slow, smooth, not heavy pull. No safety or slide motion to worry about.
If you think 327 may be much recoil, S&W 617 or similar (8-10 shot 22lr revolver) should be able to have the same stuff done. While it may be tempting, avoid 22wmr (22 magnum) out of a pistol - it is one of the few rounds I'll wear both my normal ear plugs AND a set of muffs to shoot from a hand gun (30 carbine is another)