Chloroquine?

[Mahler9th]

"Interesting info:

https://www.powerlineblog.com/archives/2020/03/brian-sullivan-what-is-to-be-done.php

Our friend Brian Sullivan is the founder and chief executive officer of a sophisticated biomedical company. In commenting on the Wuhan virus and related issues, John and I have been guided by his review of the literature and his analysis of the data. I asked Brian for his thoughts following yesterday’s confusing White House task force briefing with FDA Commissioner Stephen Hahn. Brian has responded as follows:"

An interesting perspective. I watched and listened closely to POTUS and Hahn and the rest when they were on TV. I did not get any impression of hesitancy from Hanh-- what I got was an impression that he wanted to be crystal clear and candid.

I sensed he was on a mission, and that was to be clear, truthful and candid.

I cannot imagine a much harder set of circumstances than what all of those folks face in terms of communication.

I am sure Mr. Sullivan has lots of experience dealing with FDA (I think he runs Celcuity, and if so I am pretty sure we have professional contacts in common).

I have lots of experience with FDA too-- more on the equipment and device side. But I have some on the mixed side as well (device/drug).

I am not sure what the current global regulatory situation is, but my hypothesis is that government folks like those in our FDA are taking measured steps and making ongoing risk/reward decisions with alacrity and resolve.

I also suspect that folks on the industry side are doing likewise.

And efforts are global.

And hopefully they are working tightly together and empowered.

And thanks for your post Geneman.

Not gonna start drinking gin... but maybe will stash a bottle away.

[red-beard]

Originally Posted by gacook

When were you taking it for Malaria? When I took Malaria pills (1999-2000 timeframe), it was 1 a day--starting a week prior to the deployment and continuing a week after the deployment. To be perfectly frank, I haven't had any real sickness--even a mild flu--since then...

1988-1990, India and Pakistan for prevention of Malaria. I was a Field Engineer with GE

[Mahler9th]

I just read the "About Us" on the Powerlineblog site.

I understand more now.

Bunch of fellow Dartmouth alumns involved.

[tdw28210]

Originally Posted by techweenie

Well, on the one hand you have Dr Fauci saying it's not determined yet, and on the other, well, you fill in the qualifications of the 'heard on the internet or at the press conference' source.

Yeah, I like Dr. Fauci too, but I sure hope Elon's hunch is right. It's not like we are talking about leeches or some unproven, never-used-before drug.

Steven Seedhouse, a biotech analyst at Raymond James, said chloroquine was just as promising as any treatment option for COVID-19. That includes remdesivir, an antiviral drug being developed by the giant biotech company Gilead Sciences that World Health Organization officials have called "the most promising candidate" for COVID-19 treatment.

He recently analyzed the early evidence for three top drugs being tested for COVID-19 — remdesivir, chloroquine, and Kaletra, an HIV drug sold by AbbVie — and concluded that chloroquine was the most promising candidate.

"If we had to pick one of the three at this point that actually seems most likely to have the biggest impact on treating COVID-19 in the coming months/years, it would be chloroquine," he said.

Early reports about chloroquine's effectiveness have also caught the attention of Elon Musk. The Tesla CEO tweeted on Monday that it might be worth considering chloroquine for COVID-19, saying the drug saved his life when he faced a serious case of malaria.

[Geneman]

The zinc releas and “ direct “ inhibition of viral replication are all way way secondary effects. I do not believe that science at all. You would see the same by dumping all temperature cheer or any other off the shelf suds. Real mech. Worked out decades ago.

[pmax]

https://med.umn.edu/news-events/covid-19-clinical-trial-launches-university-minnesota

[93nav]

2020-03-20

In Australia. They are doing a combined chloroquine and Kaletra treatment. I read someplace else that Kaletra was not effective.


https://www.dailymail.co.uk/news/article-8134785/Has-Australia-coronavirus-cure-Patients-successfully-treated-HIV-malaria-medication.html

[Chocaholic]

Have heard that chloroquine has been given along with zinc with some success.

[sc_rufctr]

Originally Posted by Brown747

https://m.youtube.com/watch?v=rRgnQs6D1u8&feature=emb_title

"I'd have every person with a sewing machine making masks..."

[cstreit]

Originally Posted by gacook

When were you taking it for Malaria? When I took Malaria pills (1999-2000 timeframe), it was 1 a day--starting a week prior to the deployment and continuing a week after the deployment. To be perfectly frank, I haven't had any real sickness--even a mild flu--since then...

Same here. Anti-malarial dose before and while in India

[sc_rufctr]

I took Anti-malarial drugs on and off for almost a decade (Chloroquine derivatives).
This began in the late 80s. I don't remember having any side effects.

If it's helpful then why not?

[skinnerd]

In France they are testing hydroxychloroquine and azithromycin used together.
The results look promising for treating and reducing the duration of the virus.
I think some doctors are already trying this approach in the US.



https://techcrunch.com/2020/03/19/french-study-finds-anti-malarial-and-antibiotic-combo-could-reduce-covid-19-duration/

[tdw28210]

Tiny sample, but not exactly "anecdotal".

https://www.deseret.com/u-s-world/2020/3/18/21183917/coronavirus-covid19-france-drug-trial-professor


Professor Didier Raoult, who works for the infection hospital l’Institut Hospitalo-Universitaire (IHU) Méditerranée Infection in Marseille, published a new video in which he explained that the COVID-19 patients who were treated “with the drug chloroquine had seen a rapid and effective speeding up of their healing process, and a sharp decrease in the amount of time they remained contagious,” according to The Connexion, an English site for French news.

Chloroquine has previously been used to prevent and treat malaria.
The drug was offered to 24 patients, who were among the first 24 to become infected in France’s southeastern region.
Patients were given the drug for 10 days. Researchers monitored the patients since the drug can cause severe side effects.
Raoult said those who did not receive the drug were still contagious after six days. Those who tried the drug were only 25% contagious, though.

[DanielDudley]

Azithromycin would be used to treat bacterial pneumonia, and other lung infections that are super easy to get when you are very sick with COVID-19.

I think the dosage is about 7 times that used to treat malaria. Hence the concern about side effects. As stupid as it may sound, I wonder how well it might work with zinc supplements.

[techweenie]

I have read that hydroxychloroquine (Plaquenil) plus Azithromycin should NOT be taken for #COVID19 UNLESS a doctor prescribes it.

Allegedly, both drugs affect the QT interval of your heart and can lead to arrhythmias and sudden death, especially if you are taking other meds or have a heart condition.

A side effect of hydroxychloroquine is irreversible blindness.

[red-beard]

Originally Posted by techweenie

I have read that hydroxychloroquine (Plaquenil) plus Azithromycin should NOT be taken for #COVID19 UNLESS a doctor prescribes it.

Allegedly, both drugs affect the QT interval of your heart and can lead to arrhythmias and sudden death, especially if you are taking other meds or have a heart condition.

A side effect of hydroxychloroquine is irreversible blindness.

I wish, with some of the stuff I saw while I was taking it...

[red-beard]

For example

[Rtrorkt]

plus another downside is this drug is needed by long term Lupus sufferers who if they cannot keep taking have some very significant side effects. Since folks are running to get this drug it is depriving others who need it based on clinical experience. Cause and effective of talking about feelings rather than science

[looneybin]

Originally Posted by vash

i would piss on a sparkplug if i thought it would help

Nice “Wargames” quote there

[Steve Carlton]

Nice avatar, looneybin!