COVID Treatment Advances

[pmax]

Originally Posted by jyl

You're asking is there a treatment suitable to give someone who's been diagnosed with Covid but whose symptoms are just starting and mild (not hospitalized, not on supplemental oxygen)?

AFAIK, right now the only pharmaceutical treatment shown to be effective in that situation is Regeneron's antibody cocktail REGN-COV. See summary of phase 3 data https://investor.regeneron.com/news-releases/news-release-details/phase-3-trial-shows-regen-covtm-casirivimab-imdevimab-antibody

"Effective" means that it substantially reduced the risk of hospitalization or death (by 70% or so), not that it is a silver bullet. I don't know of data for REGN-COV in the Delta variant but I think it is likely to retain effectiveness there as well. Lilly's antibody drug was withdrawn because it isn't effective against some variants. New antibody cocktails are being developed.

REGN-COV is currently available under EUA as an infusion. It hasn't been used all that much (I think several million persons in the US have received it so far) because it isn't that practical to administer a 30-60 minute infusion to 66,000 new Covid patients persons per day. There are around 3,600 infusion centers in the US, very roughly 20 chairs/beds per, so do the math on how infusion capacity. It is even more limited because infusion is typically used for cancer patients, who you really don't want exposed to Covid patients. There are home infusion services but there manpower is the capacity limiting factor.

Of course, if you're Donald Trump, Chris Christie, or other VIP you'll get REGN-COV, and if you're assertive and educated patient able to advocate for yourself, you can likely get it, especially if you're at higher risk.

REGN-COV is being developed in a subcutaneous administration form, which could really relieve the capacity limitations. Watch for that.

[jyl]

See discussion in other thread about this - ivermectin meta-analysis was falsified.

Originally Posted by tdw28210

From April of this year.

This seems to be good news, but not for anything new in the world or Rx, likely contributing to it being somewhat overlooked.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088823/

Conclusions:

"Meta-analyses based on 18 randomized controlled treatment trials of ivermectin in COVID-19 have found large, statistically significant reductions in mortality, time to clinical recovery, and time to viral clearance. Furthermore, results from numerous controlled prophylaxis trials report significantly reduced risks of contracting COVID-19 with the regular use of ivermectin. Finally, the many examples of ivermectin distribution campaigns leading to rapid population-wide decreases in morbidity and mortality indicate that an oral agent effective in all phases of COVID-19 has been identified.
Keywords: ivermectin, COVID-19, infectious disease, pulmonary infection, respiratory failure"

[jyl]

Originally Posted by pmax

Thanks! I missed that.

[Sooner or later]

Originally Posted by pmax

Remember this thread? Good times! EUA! Not available!

http://forums.pelicanparts.com/off-topic-politics-religion/1095601-tell-me-again-how-its-safe-12.html

Originally Posted by pmax

Speaking of treatments, this is news to me.

One injection !
Why is this not available everywhere ?


Roche, Regeneron's REGEN-COV cuts symptomatic COVID-19 by 81% among household contacts

Regeneron Pharmaceuticals and partner Roche on Monday reported positive results from a Phase III study, showing that a subcutaneous formulation of the antibody cocktail REGEN-COV (casirivimab with imdevimab) reduced the risk and burden of COVID-19 among household contacts of SARS-CoV-2-infected individuals. According to the findings, REGEN-COV cut the risk of symptomatic COVID-19 by 81% among people who were not infected when they entered the 2069A trial, meeting the primary endpoint.

"Convenient subcutaneous administration of REGEN-COV could help control outbreaks in high-risk settings where individuals have not yet been vaccinated, including individual households and group living settings," commented Myron Cohen, who helped lead the study on behalf of the US National Institute of Allergy and Infectious Diseases.

Originally Posted by Sooner or later

No way, man. EUA! So bad they have to monitor you for an HOUR after injection!
These reactions may be severe or life threatening! And it is authorized for 12 year olds! Insanity!
https://www.regeneron.com/medicines/casirivimab-imdevimab

Originally Posted by Sooner or later

https://www.regencov.com/hcp/resources/faq?utm_source=google&utm_medium=ppc&utm_campaign=Sitelink&utm_content=FAQ&utm_term=regen-cov2&gclid=CjwKCAjwuIWHBhBDEiwACXQYsWcCyBCg6gueJJfm9Wj6 jr6oe9bWhjHBo_1g_BNTPueUb4pyLJX4lBoCurEQAvD_BwE

How can treatment sites order/re-order REGEN-COV?
To order REGEN-COV, treatment sites should visit the web order sheet to place a direct order request. Treatment sites should also review the ASPR direct ordering process guide.

[pmax]

As they say, your mileage will vary.

Last time I checked that "official" site, there was one, as in one not two, claimed, their terminology, seat in the vicinity at Kaiser I believe. The others say call and confirm for availability or something to that effect.

[Sooner or later]

Originally Posted by pmax

As they say, your mileage will vary.

Last time I checked that "official" site, there was one, as in one not two, claimed, their terminology, seat in the vicinity at Kaiser I believe. The others say call and confirm for availability or something to that effect.

Why would you put a rushed, untested EUA into your body? It may kill you in 5 years. Read that "Important Safety Information".

[javadog]

Originally Posted by Sooner or later

Why would you put a rushed, untested EUA into your body? It may kill you in 5 years.

You talking about the vaccine, Willis?

[Sooner or later]

Originally Posted by javadog

You talking about the vaccine, Willis?

I am talking about Regen-Cov that is available only because of EUA.

[javadog]

Shucks, I thought you were talking about the vaccines, which are available only because of EUA.

[Sooner or later]

Originally Posted by javadog

Shucks, I thought you were talking about the vaccines, which are available only because of EUA.

I would accept both. How many times have we heard about rushed EUA status and the risks involved?

[javadog]

Until the Covid vaccines came along, I hadn’t paid much attention to anything that received an EUA.

As a general principal, I am risk-averse, so I would probably avoid being on the leading edge of anything new like that. Knowing what I know about the vaccines at this point, there is absolutely no way I would make the decision today to get the vaccine.

[Sooner or later]

[Chocaholic]

Just skimmed much of this but are you saying the Rgeneron EUA is high risk, but the vaccine EUA is not?

[Sooner or later]

Originally Posted by Chocaholic

Just skimmed much of this but are you saying the Rgeneron EUA is high risk, but the vaccine EUA is not?

No, I am saying I would take either one since they are both low risk.

Pmax wants the limited tested EUA Regen-Cov. The one that can lead to a worsening symptoms, the one that can lead to death, the one where not a lot of people that have been given Regen-Cov.

Seems the EUA and unknown risks aren't a problem.

[pmax]

Originally Posted by Chocaholic

With 200 news stories each day about vaccines, exactly 0 each day regarding treatment advances, it seems a topic worthy of discussion.

Are we still talking about treatments and not vaccines ?

[Sooner or later]

A total of 1505 people were enrolled in the trial. Approximately half received the drug cocktail (their term) have received a placebo.

[Sooner or later]

[Esel Mann]

Not a treatment per-se but anything to boost the immune system will certainly help...

https://www.the-sun.com/lifestyle/3381486/can-masturbating-boost-your-immune-system-fight-covid/

Looks like i've got a busy weekend ahead. By monday morning my imune system should be off the charts.

[Rawknees'Turbo]

^^^

EM, something tells me that YOU are already poised to live to at least 150, with no diseases or genetic malfunctions whatsoever during that time (maybe just some wrist/hand arthritis and maybe some debt thanks to spending lots of coin on various "devices" to aid your immunotherapy routines )!

[Chocaholic]

They say blindness is possible though. How’s your vision these days EM?