COVID-19 drugs that work

[Shaun @ Tru6]

Originally Posted by Chocaholic

Stat sig. cool buzz words. And used it twice.

This is an interesting post.

When I see things I don't know, I'm curious to learn what they are and look them up. Nice to learn new things.

I'm not so sure we want to shame intelligent people for sharing their knowledge in our developing Idiocracy. I certainly value contributions from intelligent, knowledgeable people like jyl, tadd and others like them. We all should.

[KFC911]

I trust the opinions, statistical analysis, trials, and the interpretations of such...out of NC professionals....moreso than amateurs anywhere...jmho.

Duke, UNC, the scientists at RTP and LabCorp, etc. have been on this to the best of their abilities for several months now.

We'll get there but....armchair Monday morning QB'ing in hindsight....is just that, nothing more, nothing less....jmo.

[tadd]

Link to a study that spells out the costs of the synthesis of the various possible COVID drugs.

Virus Eradication-Detail

Could make most of those in my basement .

[jyl]

Originally Posted by Shaun @ Tru6

This is an interesting post.

When I see things I don't know, I'm curious to learn what they are and look them up. Nice to learn new things.

I'm not so sure we want to shame intelligent people for sharing their knowledge in our developing Idiocracy. I certainly value contributions from intelligent, knowledgeable people like jyl, tadd and others like them. We all should.

“Stat sig” is common abbreviation for “statistically significant”, usually that means the p-value is < 0.05 but there’s other criteria too.

Trials can appear to show a benefit, but without statistical significance you can’t have confidence the benefit is real.

I’m mostly posting with my phone these days. I use a “gesture“ keyboard but that software has gotten worse, no idea why, and I’m getting all kinds of weird word choices. So I’m using abbreviations more.

[KFC911]

Originally Posted by tadd

....
Could make most of those in my basement .

Isn't yer meth lab profitable enough ?

[RWebb]

Originally Posted by island911

Yep. I've known about this anti-viral for months; and posted about it 6 weeks ago. FINALLY it is Uuge news.

you and tabs

[93nav]

The Gilead website states manufacturing Remdrsivir is a long and slow process. I would have thought it to be expensive. It is also an IV drug, more $$.

https://www.gilead.com/purpose/advancing-global-health/covid-19/working-to-supply-remdesivir-for-covid-19

Originally Posted by tadd

Link to a study that spells out the costs of the synthesis of the various possible COVID drugs.

Virus Eradication-Detail

Could make most of those in my basement .

[93nav]

Doing a search on this website, you were the first to mention it. Feb 10.

Originally Posted by RWebb

you and tabs

[pmax]

Well, looks like the goal posts were moved in the NIAD remdesivir trial to favor the positive outcome. This along with the pre-leak and leaking of the results, is big pharma back to their games ?

Hmmm...

[jyl]

Federal govt will control who gets remdesivir and guidelines say only those with severe disease and needing breathing assistance.

[RWebb]

will the fed cut off the remdesivir supply to PARF?

[jyl]

Feds have not done a good job centrally managing the distribution of PPE so not entirely reassured they will control the use of the only drug that so far is proven to have any efficacy.

That said, by end of year GILD expects to have produced enough to treat 1MM patients, so supply shortage in the US will be over.

I wonder if Feds will try to control GILD’s supply to other countries? Like, drug supply as political tool?

[RWebb]

depends on who is in office then

[Chocaholic]

Originally Posted by Shaun @ Tru6

This is an interesting post.

When I see things I don't know, I'm curious to learn what they are and look them up. Nice to learn new things.

I'm not so sure we want to shame intelligent people for sharing their knowledge in our developing Idiocracy. I certainly value contributions from intelligent, knowledgeable people like jyl, tadd and others like them. We all should.

Honestly, any one of us could use jargon from our areas of expertise. But this is a car forum. Seems one might want to share info in layman’s terms rather than demonstrate well...you know. .

[pmax]

Death is no longer a "primary outcome" in the Remdesivir trial.

Apparently, a heated discussion right now within the "scientfic community"...

https://www.healthnewsreview.org/2020/04/what-the-public-didnt-hear-about-the-nih-remdesivir-trial/
What the public didn’t hear about the NIH remdesivir trial

[pmax]

Good article.

https://spectator.org/a-report-from-the-front/

[group911@aol.co]

Interesting. Not peer reviewed yet.
https://www.scmp.com/news/china/science/article/3081959/coronavirus-outbreak-france-did-not-come-directly-china-gene

[island911]

Thanks for the updates jyl.

Originally Posted by RWebb

you and tabs

Originally Posted by RWebb

will the fed cut off the remdesivir supply to PARF?

Originally Posted by RWebb

depends on who is in office then

As useful as tits on a bull.

[jyl]

Originally Posted by pmax

Death is no longer a "primary outcome" in the Remdesivir trial.

Apparently, a heated discussion right now within the "scientfic community"...

The endpoint was changed during the trial, when the data was still blinded to both the NIAID and the DSMB.

I think a lot of the criticism of the trial is founded on the view that this isn’t a highly effective drug - which is true, no question, it is only moderately effective - but that’s still a good first step. In a year, it will be disappointing if remedsivir remains the standard of care.

Other criticism reflects the intricacies of drug development being suddenly of great interest to a larger audience and popular media who lack much knowledge. One of my friends, a medical researcher, was scathing about the topline data being released before the full dataset was available and about the lack of “peer review”. He didn’t realize that both are routine practices in drug clinical development.

Finally, I see all sorts of outrage about how GILD has a monopoly on this drug and will make billions on what should be free for all, usually followed by a screed about greedy US pharma companies. I disagree - private companies won’t risk billions in new drug development if they can’t make multiple billions on the less than 1% of candidates that are actually successful, GILD probably won’t make much money on remedsivir (because ask the drug used in 2020 is being donated, they won’t have much more than 2-3MM courses available in all of 2021, and the drug will probably be obsolete by 2022. Of course I do have some personal bias - hard to invest in biopharma if there’s no profits.

[RWebb]

remedsivir was developed for ebola, so you might think it could be improved for this virus

OTOH, the mode of action suggests not, and that side effects will always be present