COVID-19 drugs that work

[KFC911]

^^^^ Thanks! Some people just suck....

Would be nice if the Red Cross or some other org could do this without the price gouge imo.

[RWebb]

donating your plasma if you survived a corona virus infection is helping other people by giving them the antibodies you generated


you could do it free, or donate any payment to charity

[KFC911]

^^^^ and I would attempt to find a way....but without obscene middleman profits. Duke and Wake Forest research etc. is near me...others might not have an option...or get suckered .

[jyl]

Originally Posted by RWebb

donating your plasma if you survived a corona virus infection is helping other people by giving them the antibodies you generated


you could do it free, or donate any payment to charity

I wonder if the hospitals have organized programs to follow up with recovered patients and ask them to donate plasma? I'm surprised that I'm not seeing Red Cross campaigns on this.

[RWebb]

Yes, too bad I don't know the Chief of Staph at the local yokel hospital anymore, but I'll mention it to the usual suspects next time I see them

[pmax]

Originally Posted by jyl

Largest HCQ observational study I’ve seen. Similar results as the others.

Still a chance for HCQ in prophylaxis (prevention). Trial ongoing.

https://marlin-prod.literatumonline.com/pb-assets/Lancet/pdfs/S0140673620311806.pdf

“96 032 patients (mean age 53·8 years, 46·3% women) with COVID-19 were hospitalised during the study period and met the inclusion criteria. Of these, 14 888 patients were in the treatment groups (1868 received chloroquine, 3783 received chloroquine with a macrolide, 3016 received hydroxychloroquine, and 6221 received hydroxychloroquine with a macrolide) and 81 144 patients were in the control group. 10 698 (11·1%) patients died in hospital. After controlling for multiple confounding factors (age, sex, race or ethnicity, body-mass index, underlying cardiovascular disease and its risk factors, diabetes, underlying lung disease, smoking, immunosuppressed condition, and baseline disease severity), when compared with mortality in the control group (9·3%), hydroxychloroquine (18·0%; hazard ratio 1·335, 95% CI 1·223–1·457), hydroxychloroquine with a macrolide (23·8%; 1·447, 1·368–1·531), chloroquine (16·4%; 1·365, 1·218–1·531), and chloroquine with a macrolide (22·2%; 1·368, 1·273–1·469) were each independently associated with an increased risk of in-hospital mortality. Compared with the control group (0·3%), hydroxychloroquine (6·1%; 2·369, 1·935–2·900), hydroxychloroquine with a macrolide (8·1%; 5·106, 4·106–5·983), chloroquine (4·3%; 3·561, 2·760–4·596), and chloroquine with a macrolide (6·5%; 4·011, 3·344–4·812) were independently associated with an increased risk of de-novo ventricular arrhythmia during hospitalisation.”

I really do wish the corruption of the "scientific community" was fiction.

https://www.theguardian.com/science/2020/may/28/questions-raised-over-hydroxychloroquine-study-which-caused-who-to-halt-trials-for-covid-19

Questions have been raised by Australian infectious disease researchers about a study published in the Lancet which prompted the World Health Organization to halt global trials of the drug hydroxychloroquine to treat Covid-19.
...
Victoria’s department confirmed the study’s results relating to the Australian data did not reconcile with the state’s coronavirus data, including hospital admissions and deaths. The NSW Department of Health also confirmed it did not provide the researchers with the data for its databases.
...
“Usually to submit to a database like Surgisphere you need ethics approval, and someone from the hospital will be involved in that process to get it to a database,” he said.

[jyl]

Going to be interesting to see what this “Surgisphere database” is - if it is.

[RWebb]

https://www.the-scientist.com/news-opinion/disputed-hydroxychloroquine-study-brings-scrutiny-to-surgisphere-67595

[pmax]

https://www.thelancet.com/lancet/article/s0140673620312903

Expression of concern
Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis

[dad911]

Originally Posted by Shaun @ Tru6

Will anyone with negative side effects from hydroxchoroquine sue Trump?

Didn't Gov Cuomo demand NYC have permission to use it for treatment? Ordered docs couldn't prescribe so hospitals would have a large supply? And his brother Chris used it also.....

[Shaun @ Tru6]

Add him to the class action if he promoted using it.

[pmax]

Assuming anyone still remember this, guess what ... it's another hoax from the corrupted "scientific community".

https://www.sciencemag.org/news/2020/02/paper-non-symptomatic-patient-transmitting-coronavirus-wrong

A paper published on 30 January in The New England Journal of Medicine (NEJM) about the first four people in Germany infected with a novel coronavirus made many headlines because it seemed to confirm what public health experts feared: that someone who has no symptoms from infection with the virus, named 2019-nCoV, can still transmit it to others.

Chinese researchers had previously suggested asymptomatic people might transmit the virus but had not presented clear-cut evidence. “There’s no doubt after reading [the NEJM] paper that asymptomatic transmission is occurring,” Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases, told journalists. “This study lays the question to rest.”

But now, it turns out that information was wrong.

... the researchers didn’t actually speak to the woman before they published the paper. The last author, Michael Hoelscher of the Ludwig Maximilian University of Munich Medical Center, says the paper relied on information from the four other patients: “They told us that the patient from China did not appear to have any symptoms.” Afterward, however, RKI and the Health and Food Safety Authority of the state of Bavaria did talk to the Shanghai patient on the phone, and it turned out she did have symptoms while in Germany.

[RWebb]

https://www.the-scientist.com/news-opinion/sars-cov-2-spike-protein-shares-sequence-with-a-human-protein-67596

[pmax]

Back on the table after the hoax has been exposed.

https://www.reuters.com/article/us-health-coronavirus-who-idUSKBN23A2LT

GENEVA (Reuters) - The World Health Organization will resume its trial of hydroxychloroquine for potential use against the coronavirus, its chief said on Wednesday, after those running the study briefly stopped giving it to new patients over health concerns.

[Tim L]

https://covid19criticalcare.com/wp-content/uploads/2020/05/MATH-Release-4-24.pdf

[jyl]

HCQ failed to show benefit in the Univ Minn randomized prevention trial: persons exposed to Covid, received HCQ or placebo prophylaxis, endpoint was if they developed either lab-confirmed or symptom-inferred Covid. One can pick at the study methods and there are some weird/interesting subgroup differences, but nonetheless the large randomized controlled (and blinded) trials are starting to report and so far no evidence of HCQ efficacy. Prophylaxis was probably (opinion) HCQ’s best chance to succeed.

In other news, first randomized trial of convalescent plasma has reported, and showed efficacy in severe cases but none in critical - i.e. life threatening - cases. Which kinda makes sense, convalescent plasma is an antibody i.e. immunotherapy, and if the disease has progressed to critical, maybe too late for that. https://jamanetwork.com/journals/jama/article-abstract/2766943

[jyl]

Originally Posted by RWebb

https://www.the-scientist.com/news-opinion/sars-cov-2-spike-protein-shares-sequence-with-a-human-protein-67596

Interesting, is there a way to block furin from the cleavage site or otherwise create a therapy using this?

[Rawknees'Turbo]

^^^

Just say no to blocking cleavage from sight - that is good optical therapy!!

[RWebb]

Originally Posted by jyl

Interesting, is there a way to block furin from the cleavage site or otherwise create a therapy using this?

I dunno, but it is an area that should be looked into.

I exect people will mostly just go after the spike protein in conventional ways.

[Tobra]

Originally Posted by Shaun @ Tru6

Will anyone with negative side effects from hydroxchoroquine sue Trump?

I guarantee that someone will try.