COVID-19 drugs that work

[jyl]

Originally Posted by Rawknees'Turbo

^^^

Just say no to blocking cleavage from sight - that is good optical therapy!!

No no no, just want to block furin so the cleavage remains present !

[pmax]

Pure fraud.
The lesson here is to take everything from the "scientific community" with a grain of salt.

Lancet, NEJM retract controversial COVID-19 studies based on Surgisphere data
https://retractionwatch.com/2020/06/04/lancet-retracts-controversial-hydroxychloroquine-study/

[jyl]

Originally Posted by pmax

Pure fraud.
The lesson here is to take everything from the "scientific community" with a grain of salt.

Lancet, NEJM retract controversial COVID-19 studies based on Surgisphere data
https://retractionwatch.com/2020/06/04/lancet-retracts-controversial-hydroxychloroquine-study/

Take anything from any community with a grain of salt.

In this case, note that it was the scientific community that called out the data problems. Sort of a real time peer review.

[jyl]

https://blogs.sciencemag.org/pipeline/archives/2020/06/05/the-recovery-trial-reports-on-hydroxychloroquine

HCQ fails in large UK treatment trial. Right after failure in large in prevention trial.

Still debate over whether / how harmful the drug is, but rapidly diminishing room for debate over whether it is effective.

[tdw28210]

Originally Posted by pmax

Pure fraud.
The lesson here is to take everything from the "scientific community" with a grain of salt.

Lancet, NEJM retract controversial COVID-19 studies based on Surgisphere data
https://retractionwatch.com/2020/06/04/lancet-retracts-controversial-hydroxychloroquine-study/

Honest mistake...

[group911@aol.co]

So, the takeaway is to trust the scientists that agree with a persons preconceived notions and call the others a fraud.

Originally Posted by jyl

Take anything from any community with a grain of salt.

In this case, note that it was the scientific community that called out the data problems. Sort of a real time peer review.

[KFC911]

Originally Posted by group911@aol.co

So, the takeaway is to trust the scientists that agree with a persons preconceived notions and call the others a fraud.

It's gotten so bad that I almost don't believe my own lies and BS these days .

[Shaun @ Tru6]

Originally Posted by Tobra

I guarantee that someone will try.

Rally attendees won't be able to.

Coronavirus Live Updates: Trump Rally Attendees Cannot Sue if They Get Covid-19, Campaign Says

For Trump campaign rallies, attendees must agree not to sue if they get the virus.

As President Trump moves to resume indoor campaign rallies, his campaign has added a twist to his optimistic push to return to life as it was before the pandemic: Attendees cannot sue the campaign or the venue if they contract the virus at the event.

“By clicking register below, you are acknowledging that an inherent risk of exposure to Covid-19 exists in any public place where people are present,” a statement on Mr. Trump’s campaign website informed those wishing to attend his June 19 rally in Tulsa, Okla. “By attending the rally, you and any guests voluntarily assume all risks related to exposure to Covid-19 and agree not to hold Donald J. Trump for President, Inc.; BOK Center; ASM Global; or any of their affiliates, directors, officers, employees, agents, contractors or volunteers liable for any illness or injury.”

Mr. Trump’s rally in Tulsa, the site of a massacre of black residents in 1921, will be on Juneteenth, a prominent African-American holiday recognizing the end of slavery in the United States. The rally will also be his first since the pandemic forced most of the country into quarantine three months ago, a campaign official said Wednesday. Polls have shown former Vice President Joseph R. Biden Jr. establishing a substantial lead over Mr. Trump.

Oklahoma, a state Mr. Trump won four years ago by 36 percentage points, began lifting restrictions on businesses on April 24 and moved into Phase 3 of its reopening on June 1, allowing summer camps to open and workplaces to return with full staffing.

Of the four states the president announced this week as sites for rallies, three — Florida, Arizona and North Carolina — are seeing rising virus caseloads, while Oklahoma’s infection numbers are steady but not falling.

The Centers for Disease Control and Prevention still recommends that people avoid mass gatherings and stay out of crowded places.

[jyl]

Large indoor political rallies with no masks - practically the definition of superspreader events.

[Rawknees'Turbo]

Originally Posted by jyl

Large indoor political rallies with no masks - practically the definition of superspreader events.

PARFish content deleted, but post kept in place so I can work towards KC's level of post-ho-ism!!!

[group911@aol.co]

No. It gets even better. Jacksonville doesn't have enough hotel rooms so they are talking about bringing in cruise ships like they did for the super bowl. They're even bringing in Darwin to captain the ship.

Originally Posted by jyl

Large indoor political rallies with no masks - practically the definition of superspreader events.

[RWebb]

don't parf the thread Rawkee

[Rawknees'Turbo]

Originally Posted by RWebb

don't parf the thread Rawkee

Good point, and fixed now.

[jyl]

Similar sorts of events
- Concerts
- Nightclubs, karoke
- Big sport events
- Crowded bars

OTOH the two hairdressers who cut hair for 140 customers while sick with Covid have apparently not infected any of those clients, despite the extended close proximity - perhaps both hairdresser and customer being masked made a difference.

[jyl]

https://www.bbc.com/news/amp/health-53061281

Dexamethasone positive data in RECOVERY trial in UK. Reduced mortality in oxygen receiving and ventilated patients by about 1/3-1/5th. This is a generic drug, a steroid, sometimes used in rheumatoid arthritis. Many other RA drugs (inflammation suppression) are in trials.

I think steroids have been used experimentally in Covid, to suppress cytokines, the issue is when to give. Logically seems like best to give in critical cases rather than mild/early stage and that’s what the trial seems to be suggesting.

[sammyg2]

Yep, not a vaccine but a promising treatment:

'Life-saving' coronavirus drug discovered by Oxford researchers
By Chris Ciaccia |

Researchers at Oxford University have discovered what is believed to be the first evidence of a drug that can reduce the risk of death from COVID-19 by up to one-third, a steroid known as dexamethasone.

The drug, which is "instantly available and affordable worldwide" and is also a steroid, was found to reduce deaths in patients receiving oxygen by one-fifth and those on ventilators by one-third, according to preliminary results released Tuesday.

"Dexamethasone is the first drug to be shown to improve survival in COVID-19. This is an extremely welcome result," Peter Horby, Professor of Emerging Infectious Diseases in the Nuffield Department of Medicine, University of Oxford, and one of the Chief Investigators for the trial, said in a statement. "The survival benefit is clear and large in those patients who are sick enough to require oxygen treatment, so dexamethasone should now become standard of care in these patients. Dexamethasone is inexpensive, on the shelf, and can be used immediately to save lives worldwide."

Scott Gottlieb, the former head of the Food and Drug Administration, called the results a "robust finding," adding it could have "meaningful" implications.

The results of the study will be released soon, the researchers said. The funding for the study was provided by the U.K. government, as well as private donors, including the Bill and Melinda Gates Foundation.

The study, known as the RECOVERY Trial, enrolled more than 11,000 patients in England, Scotland, Wales and Northern Ireland. Some 2,104 patients were randomly assigned to get the drug, while another 4,321 patients received usual care, the Associated Press reported.

Other patients received the HIV combo drug lopinavir-ritonavir, the antibiotic azithromycin; the anti-inflammatory drug tocilizumab, or plasma from recovered COVID-19 patients.

@MattHancock
WATCH: Delighted to announce the first successful clinical trial for a life-saving #coronavirus treatment- reducing mortality by up to a third & further protecting our NHS

"Since the appearance of COVID-19 six months ago, the search has been on for treatments that can improve survival, particularly in the sickest patients," Martin Landray, professor of Medicine and Epidemiology at the University of Oxford added in the statement. "These preliminary results from the RECOVERY trial are very clear – dexamethasone reduces the risk of death among patients with severe respiratory complications. COVID-19 is a global disease – it is fantastic that the first treatment demonstrated to reduce mortality is one that is instantly available and affordable worldwide."

https://www.foxnews.com/science/life-saving-coronavirus-drug-discovered-by-oxford-researchers

[cabmandone]

https://www.msn.com/en-us/health/health-news/study-finds-hydroxychloroquine-helped-coronavirus-patients-survive-better/ar-BB16hifu?ocid=msedgntp
A team at Henry Ford Health System in Southeast Michigan said Thursday its study of 2,541 hospitalized patients found that those given hydroxychloroquine were much less likely to die.

Dr. Marcus Zervos, division head of infectious disease for Henry Ford Health System, said 26% of those not given hydroxychloroquine died, compared to 13% of those who got the drug. The team looked back at everyone treated in the hospital system since the first patient in March.

[pmax]

https://www.detroitnews.com/story/news/local/michigan/2020/07/02/michigan-henry-ford-health-study-finds-hydroxychloroquine-lowers-covid-19-death-rate/5365090002/

Hydroxychloroquine lowers COVID-19 death rate, Henry Ford Health study finds
Sarah Rahal and Beth LeBlanc, The Detroit News Published 1:10 p.m. ET July 2, 2020 | Updated 6:42 p.m. ET July 2, 2020

A Henry Ford Health System study shows the controversial anti-malaria drug hydroxychloroquine helps lower the death rate of COVID-19 patients, the Detroit-based health system said Thursday.

The study analyzed 2,541 patients hospitalized among the system’s six hospitals between March 10 and May 2 and found 13% of those treated with hydroxychloroquine died while 26% of those who did not receive the drug died.

“As doctors and scientists, we look to the data for insight,” said Steven Kalkanis, CEO of the Henry Ford Medical Group. “And the data here is clear that there was a benefit to using the drug as a treatment for sick, hospitalized patients.”

The study, published in the International Society of Infectious Disease, found patients did not suffer heart-related side effects from the drug.

Patients with a median age of 64 were among those analyzed, with 51% men and 56% African American. Roughly 82% of the patients began receiving hydroxychloroquine within 24 hours and 91% within 48 hours, a factor Dr. Marcus Zervos identified as a potential key to the medication’s success.

“We attribute our findings that differ from other studies to early treatment, and part of a combination of interventions that were done in supportive care of patients, including careful cardiac monitoring," said Zervos, division head of infectious disease for the health system who conducted the study with epidemiologist Dr. Samia Arshad.

-------

https://www.henryford.com/news/2020/07/hydro-treatment-study#.Xv42C52QIRw.twitter

“The findings have been highly analyzed and peer-reviewed,” said Dr. Marcus Zervos, division head of Infectious Disease for Henry Ford Health System, who co-authored the study with Henry Ford epidemiologist Dr. Samia Arshad. “We attribute our findings that differ from other studies to early treatment, and part of a combination of interventions that were done in supportive care of patients, including careful cardiac monitoring. Our dosing also differed from other studies not showing a benefit of the drug. And other studies are either not peer reviewed, have limited numbers of patients, different patient populations or other differences from our patients.”

[jyl]

Look closer - the patients placed on HCQ were carefully chosen, they had lower cardiac co-morbidities (which tends to correlate with other co-morbidities), and they received different treatment than other patients including more steroids (which, given at the right time, has benefit, ref dexamethasone).

If you pick healthier patients for your drug trial, and then give them another drug that does work, you're going to make it look like your trial drug works.

[group911@aol.co]

It's almost like someone stands to gain something from pushing this drug. It like some sort of cartel or something.

Originally Posted by jyl

Look closer - the patients placed on HCQ were carefully chosen, they had lower cardiac co-morbidities (which tends to correlate with other co-morbidities), and they received different treatment than other patients including more steroids (which, given at the right time, has benefit, ref dexamethasone).

If you pick healthier patients for your drug trial, and then give them another drug that does work, you're going to make it look like your trial drug works.