A "Corona EpiPen" would fix this.

[island911]

Consider for a moment that the lethal mechanism of this virus is much like a peanut allergy when it kills - the body over reacts in a fast, strong effort to rid the body of a foreign invader. Of course peanut allergies constrict airways, whereas CV response (that kills) floods the lungs.

So, rather than this challenge to build respirators, how about finding a mechanism that quiets the body's over response?

[Sooner or later]

It it were only that easy.

[Ayles]

Been watching too much Star Trek.

[911 Rod]

What are you going to put in it?

[island911]

Originally Posted by Sooner or later

It it were only that easy.

Thing is the young don't seem to have this over reaction. More likely that peanuts are a larger threat to kids. Anyway, Smokers seem to be more at risk of this virus tripping their lungs. Seems that there should be some physiological angle there to lessen the chance of pneumonia.

I know a woman who had a lung transplant. She's on all sorts of drugs to keep rejection response low.

[masraum]

Originally Posted by 911 Rod

What are you going to put in it?

essential oils

[island911]

Originally Posted by masraum

essential oils

It's all a big joke, eh?

[911 Rod]

Originally Posted by masraum

essential oils

You been talking to my wife? lol

[arcsine]

Epi-pens are used to interrupt an allergic immune response to antigens and stave off anaphylaxis/death.

Exactly what should we put into a COVID-19-pen to stave off the effects of an infectious virus?

Keeping in mind that there are no know ways to kill any virus once introduced into the body without killing or significantly damaging the host too? Damping immune response will have no effect on the effects of the viral infection and would serve to worsen the disease for the patient.

[Eric Coffey]

Originally Posted by arcsine

Keeping in mind that there are no know ways to kill any virus once introduced into the body without killing or significantly damaging the host too?

No magic pill yet, but there are antibody treatments that can stop viruses from reproducing. I know they are already harvesting antibodies from known recovered folks, but that is not very efficient/scale-able. Synthesizing/cloning those antibodies is probably a better option. Or maybe targeted stem-cell/T-cell treatment, or a combo platter.

Lots of smart folks out there working on it for sure. Without the normal regulatory roadblocks, hopefully we will see an effective treatment sooner than later.

[island911]

Originally Posted by Ayles

Been watching too much Star Trek.

Originally Posted by 911 Rod

What are you going to put in it?

Originally Posted by arcsine

Epi-pens are used to interrupt an allergic immune response to antigens and stave off anaphylaxis/death.

Exactly what should we put into a COVID-19-pen to stave off the effects of an infectious virus? ....

Yeah, I'm not sure so many are focusing on the delivery method and not underlying physiological interruption. My whole point is centered about interrupting a body's over-reacting - just as an Epi-pen does.

My hope was, some here with a strong physiology background, could speak to methods used to minimize the chances of pneumonia response. I know that my 79 y/o mother was recently given some sort of shot to lower her risk of developing pneumonia.

[Rawknees'Turbo]

^^^

I wonder if it was a corticosteroid shot, such as Prednisone? I know from experience that that is a powerful anti-inflammatory, but is so by being an immunosupressant, so maybe not appropriate for virus-based illnesses.

[GaltJ]

Peanuts don’t destroy vascular permeability in the lungs.
Duh.

[911 Rod]

My concern is that if this was possible that people would keep one in their pocket and think they were invincable.

[Chocaholic]

Originally Posted by GaltJ

Peanuts don’t destroy vascular permeability in the lungs.
Duh.

That wasn’t his point.
Duh.

[Mahler9th]

I have a strong physiology background. Still have my copy of Guyton... Sixth Edition.

It might be more productive to pray for an Easter Miracle and not an Epi-Pen.

I believe that professionals working on various aspects of Rx and vaccines are carefully considering delivery mechanisms...

And I would hypothesize that commercial efforts include considerations of manufacturing, packaging, labeling, and distribution... all of the normal things.

Potentially there will be lots of commercial benefits for "winners."


I suspect you can take physiology courses on line, and learn a bunch if you are truly interested.

[island911]

Originally Posted by Mahler9th

I have a strong physiology background. Still have my copy of Guyton... Sixth Edition.

It might be more productive to pray for an Easter Miracle and not an Epi-Pen.

I believe that professionals working on various aspects of Rx and vaccines are carefully considering delivery mechanisms...

And I would hypothesize that commercial efforts include considerations of manufacturing, packaging, labeling, and distribution... all of the normal things.

Potentially there will be lots of commercial benefits for "winners."


I suspect you can take physiology courses on line, and learn a bunch if you are truly interested.

Oh fer fk sakes... what is with the focus on delivery mechanism?

I chose that Epi example only because it is widely known as a system that interrupts the body's over-reaction to a foreign substance.

Well, I suppose that we now know who here can follow detail and who can't.

[berettafan]

Originally Posted by masraum

essential oils

i had to chuckle at this.

[island911]

Originally Posted by Rawknees'Turbo

^^^

I wonder if it was a corticosteroid shot, such as Prednisone? I know from experience that that is a powerful anti-inflammatory, but is so by being an immunosupressant, so maybe not appropriate for virus-based illnesses.

This is the type of thinking I was looking for.

And you, Rawknees, were even adult enough to not jab a delivery mechanism snark in there. -We all know it would have something to do with a suppository.

[Rawknees'Turbo]

Just think, Island, if the suppository was of sufficient length and girth, then it would double as a prostate stimulation device - winning!!!