Vaccines

[jyl]

If you're interested in a readable explainer about the SARS2 vaccines in development, here is a "Tweetorial".

I've been following the programs very closely, and this immunologist is describing the clinical data accurately. He has a much more detailed Nature article as well, linked in the Tweet.

https://twitter.com/florian_krammer/status/1310372301314101250

I expect that in about 4-6 months, most of us will start having the opportunity to get vaccinated. Clinical trial failure remains possible, but I think odds are that some (enough) of these programs succeed.

[Mahler9th]

Couldn't get the link to work. I am curious howver.

I have two vaccine experts in my network, but I haven't spoken to them... waiting until Q1 when things may be more relevant. They are both busy.

[Sooner or later]

Link works for me.

[jyl]

Workd for me, I just tested it. Maybe need a Twitter account? Anyway, here's his Nature article - same but more detail. https://www.nature.com/articles/s41586-020-2798-3

The things people aren't talking about - though he hints at it - is that when vaccination is widespread, the remaining vaccine refusers may be at higher risk than they are now. Depends if the vaccines prevent upper respiratory tract infection - some don't seem to, in NHP - if not, then the vaccinated person may have an extremely mild or asymptomatic case without lung/systemic effects, which is fine for him/her, but not for the unvaccinated person they're with. And of course social distancing won't be sustained for long, after vaccination is available. If vaccine refusal rate is 50% as some expect/fear, then I think we might see infections not in fact drop, but potentially rise. Hopefully the therapeutic programs advance as rapidly as the vaccine programs.

[Mahler9th]

"Anyway, here's his Nature article - same but more detail. https://www.nature.com/articles/s41586-020-2798-3"

Thanks. I do not use Twitter. I will take a look at this article. I expect that there are and will be quite a few overview articles.

The companies working on this have to be under a lot of pressure. All employees and their families. Its gotta be hard.

[pwd72s]

Agreed...the pressure must be tremendous.

[red-beard]

On Wednesday, I get the second injection for the Sars-CoV-2 vaccine from Moderna. They are in the Phase three trial. I convinced 2 of my buddies to get the trial vaccine as well.

In the first two phases, they tested the safety and efficacy and dosage. Phase three is the "wide trial" on a bunch of different types of people.