If you can get Covid twice, how will a vaccine work?

[unclebilly]

Which of the 3 vaccines did you get? My SIL is a nurse in the UK and she gets her shot next week.

[red-beard]

Originally Posted by sewell94

As far as I know the FDA has not approved one yet.

Not yet. But I expect both mRNA vaccines will be approved before year end. Astro-Zeneca early next year and J&J in the spring.

Originally Posted by unclebilly

Which of the 3 vaccines did you get? My SIL is a nurse in the UK and she gets her shot next week.

I had the Moderna. The Pfizer vaccine (approved in UK) is quicker acting, 4 weeks to full effectiveness vs. 6 weeks for Moderna.

[Eric Coffey]

Originally Posted by red-beard

I am probably the only person on this board who has had the vaccine. I read the phase I and Phase II safety data BEFORE I signed up for the Phase III trials. They had good indication of safety and effectiveness. Phase III just puts it to a wide group. And I told many people about it and two of my friends also signed up.

I wanted to DO SOMETHING to help. And I did. And I'm still in the Study. And even if it is approved, I stay in, to see how long the antibodies last.

Yep, I'm definitely subscribing to your trials thread...And good on you for stepping up.

Originally Posted by red-beard

The best indication so far is that Antibodies last at least 200 days. They only have 200 days of data, so that is a PRETTY GOOD indication that it is very long lasting protection. And the Vaccine produces 2-4 times the antibodies of getting the virus.

If this virus remains relatively stable (which it has so far), then I'd guess immunity would last a lot longer than that even (especially when factoring in both antibody and cellular immunity).

Originally Posted by red-beard

I get people are concerned about a new vaccine. Several people on the board have said they will wait a bit. Good. That means others can get it sooner. The supply is limited. Mrs. Beard (who now regrets not getting into the trial) wants the vaccine, so life can return to normal. And I get that too!

I think people who are young/healthy/low-risk probably should wait, as to not bottleneck the system thereby preventing the higher-risk folks who want it, from getting it sooner.
Just my POV...and I am sure that has been accounted for, and will be baked into the delivery logistics/protocols to some degree anyway.

Originally Posted by red-beard

If there is a 1 in a million chance of a vaccine problem (Like the Flu Vaccine), rest well, because that would be way below the mortality rate. The Polio vaccine issue affected a few thousand kids. But that was still better than number getting polio every year. And we've basically killed that sucker off.

Yup. The only reason I brought up Dengue was because it is also a single-strand rNA virus that has similarly unpredictable outcomes and similarly triggers immune system over-response/cytokine cascades. And there were some unintended consequences from the rushed vaccine in that case (namely the lack of consideration WRT to the aforementioned antibody-dependent-enhancement phenomenon). But yeah, nothing is going to be 100% "safe". So, as long as the safety profile is within acceptable levels/margins, it should be GTG.

Originally Posted by red-beard

Finally, In doing some reading, there is a lot of similarity of COVID-19 to the common cold. No one is really talking this up, but this MAY prevent the common cold...

That would be cool, but the "common cold" is caused by several different types of viruses (some of which are much more genetically-unstable), so I'm a bit skeptical on that.

[Arizona_928]

So anyone here have covid twice?

[RWebb]

Don't worry - 100,00 healthcare workers will "test" vaccines before other get it. And elderly people in care facilities likely will too.


BTW, It's the evolutionary stability of sites on the spike protein that matter, not the virus in general. Since Mr. Spikey is the way the virus gets into cells we might expect it to be relatively stable. But one mutation has already been found. Anyway, we shall see.

I do think that the research put into this will accelerate our ability to deal with the common cold, as well as other viruses. Work on HIV helped accelerate things in general too.

[Sooner or later]

A 100,000? It will be far, far higher. It should be Into the millions in Dec.

[red-beard]

Pfizer alone, there are 59K+ doses here in Houston to be delivered immediately upon approval. This was reported on the local news.

There are about 500K doctors and 3M nurses in the USA. There are about 10,000 doctors and 60,000 nurses in Houston and surrounding area. And there are a LOT more health care workers with direct contact with patients.

[flatbutt]

Originally Posted by red-beard

The first one was actually the Polio vaccine. 1 of the 5 manufacturers screwed up the attenuation process on a batch and they GAVE polio to a bunch of kids.

BUT the Anti-vax movement ties in with the Autism movement and a doctor claimed, around 1999-2000, that there was a connection with the MMR vaccine, which was Flimsy at the time and disproven. But nothing dies on the internet.

Yeah that was the Cutter corporation. A tragic failure in manufacturing not the vaccine itself.

As for the Autism, I think that was a claim related to the preservative used in vaccines. An organomercury compound.

[Deschodt]

On the one hand, we know vaccines made the old fashioned way work - on the other this is bio engineering messenger RNA type - not really a vaccine per se, more like lines of code sent to your compiler (immune system), and while it looks promising, we really don't have a long term view on potential side effects. I find it both cool and a great new way to vaccinating, and also a tad scary.

On the flip side, since all the doctors and first responders will get it first, if this turns out to kill people a year later or give you a third testicle, we're screwed anyway as there will be no medical personel unaffected. So might as well go for it ;-) I think...

[RWebb]

the only reasonably foreseeable potential side effects would be related to the vector - it is supposed to be harmless however

the 'code' injection is not an issue