Early findings showing Pfizer vaccine is...

[cabmandone]

90% effective!?
Read about this when looking at DOW futures this morning. Up 1500!!

Hopefully some good news that carries forward! Article states Pfizer can't apply for EUA until late November because FDA requires at least 2 months to pass after last injection before EUA can be applied for.

https://www.npr.org/sections/health-shots/2020/11/09/933006651/pfizer-says-experimental-covid-19-vaccine-is-more-than-90-effective

[Sooner or later]

Buy deep freezer stock. Check out it's storage requirement.

[techweenie]

Great news for Pfizer, since immunity appears it could be limited to a couple months.
That means billions of doses until the virus becomes rare...

[GH85Carrera]

Originally Posted by Sooner or later

Buy deep freezer stock. Check out it's storage requirement.

It needs dry ice temps for storage. A deep freeze is not even close to that cold.

[Sooner or later]

Originally Posted by GH85Carrera

It needs dry ice temps for storage. A deep freeze is not even close to that cold.

I know. I was trying for a bit of levity.

[ckelly78z]

Looking forward to the market surge more than the vaccine news....but if the vaccine can create some normalcy, that will allow us to regain some rights, and freedom, bring it !

[cabmandone]

Originally Posted by Sooner or later

Buy deep freezer stock. Check out it's storage requirement.

Yeah. Was thinking the same. We discussed this last evening. 94 below!
Might want to buy into dry ice as well.

[cabmandone]

Originally Posted by GH85Carrera

It needs dry ice temps for storage. A deep freeze is not even close to that cold.

Deep freeze on roids?
94 below!! I watched a 60 minutes program on Operation Warp Speed last night. The 4 star running the show for delivery seems to have a good team together and plans for areas that don't have the ability to store at those temps.

[cabmandone]

Originally Posted by techweenie

Great news for Pfizer, since immunity appears it could be limited to a couple months.
That means billions of doses until the virus becomes rare...

Great news for all of us if the 90% holds. Then it will just be a matter of getting enough people to use it. I'm in the moment it's available to the general public.

[Neilk]

I read that Pfizer didn’t take govt money and is not part of Warp Speed, so I guess they can hose us with the price.

[Sooner or later]

Originally Posted by Neilk

I read that Pfizer didn’t take govt money and is not part of Warp Speed, so I guess they can hose us with the price.

https://investors.pfizer.com/investor-news/press-release-details/2020/Pfizer-and-BioNTech-Announce-an-Agreement-with-U.S.-Government-for-up-to-600-Million-Doses-of-mRNA-based-Vaccine-Candidate-Against-SARS-CoV-2/default.aspx

NEW YORK & MAINZ, Germany--(BUSINESS WIRE)-- Pfizer Inc. (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) today announced the execution of an agreement with the U.S. Department of Health and Human Services and the Department of Defense to meet the U.S. government’s Operation Warp Speed program goal to begin delivering 300 million doses of a vaccine for COVID-19 in 2021. Under the agreement, the U.S. government will receive 100 million doses of BNT162, the COVID-19 vaccine candidate jointly developed by Pfizer and BioNTech, after Pfizer successfully manufactures and obtains approval or emergency use authorization from U.S. Food and Drug Administration (FDA).

The U.S. government will pay the companies $1.95 billion upon the receipt of the first 100 million doses, following FDA authorization or approval. The U.S. government also can acquire up to an additional 500 million doses.

[cabmandone]

Originally Posted by Neilk

I read that Pfizer didn’t take govt money and is not part of Warp Speed, so I guess they can hose us with the price.

https://www.hhs.gov/about/news/2020/07/22/us-government-engages-pfizer-produce-millions-doses-covid-19-vaccine.html
"The U.S. Department of Health and Human Services and the Department of Defense (DoD) today announced an agreement with U.S.-based Pfizer Inc. for large-scale production and nationwide delivery of 100 million doses of a COVID-19 vaccine in the United States following the vaccine’s successful manufacture and approval. The agreement also allows the U.S. government to acquire an additional 500 million doses."

[red-beard]

Originally Posted by GH85Carrera

It needs dry ice temps for storage. A deep freeze is not even close to that cold.

Actually, the MODERNA only requires Negative 4 F (-20 C). Pfizer's requires -94 F (-80C).

Executives from Moderna and Pfizer on Wednesday separately told the Centers for Disease Control and Prevention’s Advisory Committee on Immunization Practice on Wednesday that mRNA-1273, which is Moderna’s coronavirus vaccine candidate, requires a storage temperature of negative 4 degrees Fahrenheit. BioNTech and Pfizer’s candidates, BN1162b2 and BNT162b2, need to be stored in negative 94 degrees Fahrenheit

https://www.msn.com/en-us/health/medical/moderna-and-pfizer-e2-80-99s-covid-19-vaccine-candidates-require-ultra-low-temperatures-raising-questions-about-storage-distribution/ar-BB18rb7X

[rfuerst911sc]

Was watching some news coverage this morning about the vaccine . Not there yet but promising . My hunch say's we get back to normal around June/July of next year . That prediction is straight out of the butt storage vault 😁

[Neilk]

Originally Posted by Sooner or later

https://investors.pfizer.com/investor-news/press-release-details/2020/Pfizer-and-BioNTech-Announce-an-Agreement-with-U.S.-Government-for-up-to-600-Million-Doses-of-mRNA-based-Vaccine-Candidate-Against-SARS-CoV-2/default.aspx

...
The U.S. government will pay the companies $1.95 billion upon the receipt of the first 100 million doses, following FDA authorization or approval. The U.S. government also can acquire up to an additional 500 million doses.

Thanks for the link. At $19/shot that sounds really reasonable. Let's hope they can figure out all the cold storage issues. I wonder if they could/will setup regional manufacturing plants to reduce storage issues.

[URY914]

Originally Posted by cabmando

https://www.hhs.gov/about/news/2020/07/22/us-government-engages-pfizer-produce-millions-doses-covid-19-vaccine.html
"The U.S. Department of Health and Human Services and the Department of Defense (DoD) today announced an agreement with U.S.-based Pfizer Inc. for large-scale production and nationwide delivery of 100 million doses of a COVID-19 vaccine in the United States following the vaccine’s successful manufacture and approval. The agreement also allows the U.S. government to acquire an additional 500 million doses."

Correction......

https://news.yahoo.com/pfizers-head-vaccine-development-notes-145930453.html

Pfizer distanced itself from the Trump administration's Operation Warp Speed on Monday after announcing some great news about its vaccine candidate.

Pfizer on Monday revealed that a first interim analysis suggested that its COVID-19 vaccine is more than 90 percent effective, and Vice President Mike Pence said that this was "thanks to the public-private partnership forged" by President Trump. But The New York Times reports that Dr. Kathrin Jansen, Pfizer's head of vaccine research and development, "sought to distance the company from Operation Warp Speed," the Trump administration's effort to speed up development of a coronavirus vaccine, and from politics in general.

"We were never part of the Warp Speed," Jansen told the Times. "We have never taken any money from the U.S. government, or from anyone."

Pfizer did announce in July a $1.95 billion agreement with the U.S. government for 100 million doses of its COVID-19 vaccine candidate. But Bloomberg notes that "among the frontrunners, [Pfizer's] is the only vaccine project that did not take funding from the White House-led Operation Warp Speed program to bolster research, development or manufacturing." Pfizer CEO Albert Bourla had prevously touted this fact.

[jyl]

My best guess is that Pfizer's vaccine will be directed to larger cities and larger hospitals while Moderna's vaccine, which is very likely to report positive data this month as well, will be directed to smaller cities and facilities.

Moderna will have less supply than Pfizer, but has less stringent cold chain requirements. Astrazeneca's vaccine is only a month or so behind in its clinical trials, and has less demanding cold chain requirements IIRC.

The price Pfizer is initially charging ($20/dose, or $40/person) is similar to other vaccines, and I expect the vaccine will be provided free or nearly free to the consumer.

In general, this data is good news for all the vaccine programs.

[stevej37]

Originally Posted by GH85Carrera

It needs dry ice temps for storage. A deep freeze is not even close to that cold.

I've got a 'cool collar'...will that work?

[MBAtarga]

Any of you "experts" understand how Pfizer and Moderna vaccines are unique from the others? They are using a new technology - mRNA - which has never been used in vaccines. I've read of some experts that are concerned with it's approach. It actually changes every cell in the human body..

https://www.independent.co.uk/voices/coronavirus-vaccine-covid-19-cure-doctor-moderna-novavax-oxford-a9523091.html

Many vaccines, like for influenza a.k.a flu, use an inactivated virus that is destroyed by heat or chemicals like formaldehyde so that it can elicit an immune response without infecting you. Others — like for measles, mumps, and rubella — use a live attenuated virus that is cultivated in such a way that it makes the virus weak and unable to hurt you but still able to train your immune system to fight it. Moderna’s messenger RNA vaccine, on the other hand, is completely new and revolutionary to say the least. It uses a sequence of genetic RNA material produced in a lab that, when injected into your body, must invade your cells and hijack your cells’ protein-making machinery called ribosomes to produce the viral components that subsequently train your immune system to fight the virus. In this case, Moderna’s mRNA-1273 is programmed to make your cells produce the coronavirus’ infamous spike protein that gives the virus its crown-like appearance (“corona” is crown in Latin) for which it is named.

In many ways, the vaccine almost behaves like an RNA virus itself except that it hijacks your cells to produce the parts of the virus, like the spike protein, rather than the whole virus. Some messenger RNA vaccines are even self-amplifying. That means they encode not only the protein antigen of interest to elicit an immune response but also produce their own RNA dependent RNA polymerase, so that they can force the cell to replicate more copies of it. At that point, it will be hard to convince conspiracy theorists and anti-vaxxers that a self-amplifying messenger RNA vaccine is not an artificially created self-replicating virus. In fact, public acceptance of this new paradigm is not something to be easily dismissed nor taken for granted. There are unique and unknown risks to messenger RNA vaccines, including the possibility that they generate strong type I interferon responses that could lead to inflammation and autoimmune conditions.

[Ryan_Cunningham]

I won't be initially taking it, nor will my wife or nearly three year old daughter. If I/we were very old or sick, potentially. But it isn't worth the risks that we really have no idea about.